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At first the Biochemistry section was attached with department of Physiology. It was reorganized in 1949 after amalgamation with chemistry section under Prof R. K. Baruah and Dr R.L. Nath. Late Dr R.K. Baruah was the architect for the present Bio-Chemistry department and Dr R Hussain was the first Medical Demonstrator to join the department in 1954. After Prof. R. K. Baruah left to join Gauhati University, Dr. J. N. Baruah, Dr. A. K. Saikia and subsequently Dr R Hussain joined as Professor. MD in Bio-chemistry was started in 1970. The research work of Prof. R. Hussain on different aspects of Iron metabolism has been incorporated in several text books. After Prof. R. Hussain, Dr. G. C. Baruah joined as Professor and Head of the Department. When Prof. G. C. Baruah assumed charge of Principal 1997, Dr. B. Begum joined as the Professor & Head of Department. After retirement of Dr. B. Begum, Dr. Dilip Sharma became the Head of the Department in 2002. Presently the department is headed by Dr. (Mrs) R. Changkakoty who took charge in Aug 2003.